What exactly is Noxtee?
It's a 2-phase nightly capsule routine designed to address the relay station behind your ear — the dorsal cochlear nucleus — the part of your auditory pathway the audiogram doesn't measure.
Phase 1: L-theanine and saffron extract calm the cortisol-axis stress that's been wearing the inhibitory brakes down all day.
Phase 2: 3,000mg glycine and magnesium bisglycinate refill the two natural brakes — magnesium and glycine — at research-strength doses.
Most "tinnitus" formulas (Lipo-Flavonoid, Quietum Plus, Tinnitus 911) target the cochlea or throw a kitchen-sink blend at the ear. The cochlea is the speaker. The relay is the amplifier. Most "calm" formulas only do trace amounts of step 2 ingredients — 100mg of glycine, 50mg of magnesium oxide. Noxtee does both phases, at the doses published research uses, in the right order. That's why patients who'd already tried everything saw something different on Noxtee.
90 nights to feel the night hold. If it doesn't, keep what's left — every cent back, no return shipping required.
My tinnitus has wrecked my sleep for years. Is this affecting my heart?
Probably more than your GP has told you.
Here's the chain nobody connects. Every night the relay over-fires, your sympathetic nervous system stays in fight-or-flight while you're trying to sleep. Cortisol stays elevated. Your blood pressure does not dip the way it's supposed to during sleep — it stays elevated for eight straight hours, every night, for years. That is the load behind the cardiac events that show up in women in their 50s and 60s — events that should be happening twenty years later.
Sofi et al. 2014 meta-analysis: chronic insomnia is associated with roughly a 45% increase in cardiovascular mortality. The 2026 review in Nature Reviews Neurology confirmed the brake-failure mechanism behind it.
Noxtee does reload the two brakes that quiet the relay so your nervous system can downshift at night the way it's supposed to. The cardiovascular risk pathway runs through chronic broken sleep. That's where Noxtee starts.
If you don't feel the night hold within 90 nights, keep what's left and we refund every cent.
My audiogram came back normal. Is this even for me?
Yes. In fact, it's specifically for you.
The audiogram tests the cochlea — the speaker. The signal that becomes the ringing fires one stop upstream, at the dorsal cochlear nucleus — the amplifier. The audiogram cannot reach that relay. So your test was honest. It just wasn't looking where the ringing actually fires.
A "normal audiogram" is not a clean bill of health. It is the result that closed your ENT's file the moment the cochlea checked out — while the relay above it kept firing every night. The relay was never on the test.
If your audiogram came back normal, your ENT told you to "learn to live with it," and your nights are still wrecked — Noxtee was built specifically for you. 90 nights to feel the difference. Worsening-protected refund.
What if this is just another supplement that doesn't work?
Fair question. You've probably already spent $300 to $1,500 on Lipo-Flavonoid bottles, Tinnitus 911, magnesium oxide pills, melatonin gummies, lavender oil, white noise machines, and a night guard. None of it touched what's actually firing.
Noxtee is the only nightly routine on the market dosed for the relay junction upstream of the cochlea. The doses aren't marketing — they're what the research uses:
3,000mg glycine. The Yamadera 2007 dose.
200mg magnesium bisglycinate. The bioavailable form that crosses the blood-brain barrier.
200mg L-theanine. The trial-grade dose.
28mg saffron extract. The mood and sleep-quality research dose.
90 nights to feel the night hold. Worsening-protected refund — if your nights feel worse, not better, contact support, keep what's left, every cent back. No return shipping. No chat queue. No questions.
The only risk is staying exactly where you are.
If this is real, why hasn't my ENT or doctor mentioned it?
Because the relay junction isn't on their test, and the formulation isn't a prescription.
ENTs are trained to read cochleas. The dorsal cochlear nucleus sits in the brainstem — outside their imaging, outside their certification, outside the audiogram. When the test comes back clean, the case closes. That's not malpractice. That's the limit of the tool.
The 2026 Nature Reviews Neurology review on glycinergic and NMDA modulation at the dorsal cochlear nucleus is recent. Yamadera 2007 sat shelved for over fifteen years before the field caught up. The doses Noxtee uses are research-grade, not prescription-grade — your ENT is not licensed to prescribe a nightly routine. They are licensed to test the cochlea and refer.
The reason most patients hear about this from each other before they hear it from a specialist is that the gap between published neurology and ENT practice is roughly fifteen years. Noxtee is what closes that gap.
How is this different from Lipo-Flavonoid, Quietum Plus, or Tinnitus 911?
We get this question more than almost any other.
Lipo-Flavonoid is bioflavonoid-based. It targets vascular flow at the cochlea. It's been on the shelf since the 1960s and it does not touch the relay junction at the dorsal cochlear nucleus. If your audiogram came back normal, Lipo-Flavonoid was solving the wrong organ.
Quietum Plus is a proprietary blend. The label hides individual doses behind the "proprietary blend" label so you cannot see how much of anything is in it. You're paying for a marketing label, not a verifiable research dose. Real biology requires real doses you can read on the supplement panel.
Tinnitus 911 sells a vitamin and herb blend marketed primarily through aggressive paid placements. None of its ingredients are dosed for the relay junction. It relies heavily on bioflavonoids and surface-level vitamins — nothing that reaches the inhibitory brakes at the dorsal cochlear nucleus.
Noxtee uses 4 ingredients, all individually disclosed at research-grade doses, all targeting the actual junction where the ringing fires. No proprietary blend. No bioflavonoid theater. Real doses, the order they need to be taken, the form that reaches the brain.
90 nights to compare it side-by-side. If it doesn't outperform whatever you're taking now, keep what's left and we refund every cent.
I'm on a statin, BP medication, or blood thinner. Is this safe?
Yes — and this is the single most common medication stack we see among Noxtee buyers.
Noxtee contains no synthetic compounds and no prescription-active ingredients. Just L-theanine, saffron extract, glycine, and magnesium bisglycinate. All four are widely tolerated alongside:
Statins (atorvastatin, rosuvastatin, simvastatin)
BP medications (lisinopril, losartan, amlodipine, metoprolol)
Blood thinners (apixaban, warfarin, clopidogrel)
SSRIs and anti-anxiety medications
Prescription sleep aids (zolpidem, eszopiclone)
Thyroid medications (separate by 4 hours)
Magnesium bisglycinate at 200mg is well below the threshold associated with any clinical interaction. Glycine at 3,000mg is the dose used in the Yamadera trial — published, peer-reviewed, well-tolerated.
If you are on a prescription, run the ingredient list past your prescribing doctor before you start. Email contact@noxtee.com and we'll send the full dose breakdown — print it, bring it to the appointment.
Why specifically 3,000mg glycine? Is that safe at that dose?
Yes — and it's the only dose with measurable sleep-quality data behind it.
Yamadera et al. 2007 measured sleep-quality changes at exactly 3 grams glycine, 30 to 60 minutes before bed. Lower doses (500mg, 1g) did not produce the same effect on subjective sleep quality or on polysomnographic measurements. The biology requires the dose.
Glycine itself is one of the most abundant inhibitory neurotransmitters in your nervous system. Your body produces it. You consume it from protein. A cup of bone broth contains roughly 3 to 4 grams. The dose is well within the natural range — it's just concentrated and timed for the window when your relay needs it most.
Most "calm" or "sleep" gummies use 100 to 500mg of glycine — a marketing gesture, not a therapeutic dose. Noxtee uses the trial dose. 3 grams. Every night. That's why the brake actually reloads.
What if I've tried everything and nothing works?
That's the most common starting point we see. Most people who find Noxtee have already done:
The magnesium oxide. The Lipo-Flavonoid (sometimes for years). The Quietum Plus or Tinnitus 911. The melatonin gummies. The valerian root. The lavender essential oil on the pillow. The white noise app, then the fan, then the second white noise app to mask the first. The ashwagandha. The L-theanine on its own. The night guard. The four-figure ENT bills. The "have you tried meditation" from a well-meaning friend.
None of it worked because none of it reached the relay junction.
The cochlea was the wrong target. The ear muscle was the wrong target. The melatonin half-life was the wrong target. The relay junction at the dorsal cochlear nucleus — the place every signal from your ear, jaw, and neck has to pass through on its way to your brain — was the missing target every single one of those products skipped.
Noxtee starts where everything else stopped. 90 nights at the trial dose. Worsening-protected refund.
How long until I feel results?
The wind-down change comes first. Most people notice the bedtime bracing — the 9:30 PM "what is the room going to sound like" anticipation — easing up by night 5 or 6.
The 3 AM wakeup pattern usually starts breaking around week 3. When you do wake up, the night doesn't restart from zero — you fall back asleep faster.
Mornings start feeling less like a verdict by week 5 or 6. The "how loud is it today" first thought fades.
The full pattern shift takes 90 nights — which is why the trial window is 90 nights, not 30. Some bodies respond faster, some slower. Magnesium and glycine reload over weeks, not hours. The relay has been running on empty for years. Reloading both brakes consistently takes the time it takes.
The 90-night worsening-protected guarantee covers you either way.
What if it works for other people but not for me?
Every nervous system in human biology runs the dorsal cochlear nucleus on the same two inhibitory mechanisms — magnesium ion blockade at the NMDA receptor, and glycine inhibition at the receptor downstream. That's not a regional difference. Not a Hashimoto's-vs-non thing. Not a "my body is unique" thing. That's basic neurology, in every textbook.
Whether your gauntlet history has 2 specialists or 7 in it, whether you've worn a night guard for 6 months or 16 years, whether you have hearing aids or not — the relay still runs on those two brakes. Noxtee refills them.
If your nights feel worse, not better, after 90 nights — contact support, keep what's left, every cent back.
Will it work if I clench or wear a night guard?
Yes. And this is one of the reasons Noxtee works for people who saw their dentist before they saw an audiologist.
The dorsal cochlear nucleus is where signals from your jaw, your neck, AND your auditory nerve all converge. Three nerves, one junction. Clenching feeds the same junction that's already over-firing from the auditory side.
A night guard protects your teeth from the grinding. It does not protect the relay from the signal. The signal still arrives. The brakes still get burned through. The 3 AM wakeup still happens.
Keep wearing the guard for your teeth. Take Noxtee for the relay the guard doesn't reach.
Are there any side effects? Is it habit-forming?
Noxtee is non-habit-forming. Contains no melatonin, no GABA agonists, no benzodiazepines, no kava, and no sedating antihistamines — none of the compounds that create dependency or downregulation.
Glycine, magnesium, L-theanine, and saffron are well-tolerated. Glycine in particular is one of your nervous system's own inhibitory neurotransmitters — your body makes it. Magnesium bisglycinate at 200mg is well below any threshold associated with side effects in published research. Most people experience no side effects at all.
Do I have to take it forever?
No. The goal is to restore the routine, not create a dependency.
Many people take Noxtee nightly for 90 to 180 nights, find their pattern stabilizes, then either reduce to a few nights a week as needed or stop entirely. Some keep taking it nightly because the wind-down support is something they want every night.
Your body still produces glycine on its own. You still process magnesium from food. Noxtee is supporting those systems at the relay junction during the years they're depleted. Once the pattern shifts, your body keeps making and using both — the same way it always has.
Stop anytime. No tapering protocol. No withdrawal. No rebound.
I've been dealing with this for 10, 15, 20+ years. Is it too late?
No. The dorsal cochlear nucleus does not have an expiration date.
Your nervous system still uses the same two inhibitory mechanisms it used the night this started — whether that was 2014 or 1998. Magnesium ion blockade. Glycine inhibition. Both still work at the receptor level whether you're 35 or 75. The brakes can be refilled at year 1 or year 21.
Some of the strongest pattern shifts we see come from people who'd been "managing this" for 10, 15, 20 years and had stopped expecting anything to change. The biology doesn't care how long it's been. It cares whether the inputs are there.
If 90 nights at the trial dose don't shift your pattern — keep what's left, every cent back, no questions.
I'm scared to hope again.
We know.
That might be the most honest sentence on this entire page. You've been let down by 4 specialists, every supplement on the shelf, two different night guards, and the audiogram that came back "normal" while your nights kept falling apart. Protecting yourself from another disappointment feels safer than trying.
We can't promise you a miracle. We can promise you this:
The mechanism is real. The doses are at research-grade strength. Yamadera 2007 measured the glycine effect at 3 grams. The 2026 Nature Reviews Neurology review confirmed the brake-failure pathway. The biology is universal — every nervous system runs on these two brakes.
90 nights to feel the night hold. Worsening-protected refund — if your nights feel worse, not better, keep what's left and we refund every cent. No return shipping required. No chat queue. No questions.
The only real risk is staying exactly where you are — for another year, another decade, another 3 AM wakeup that starts the night over.
The brakes can still be refilled. The relay can still quiet down. The version of you who fell asleep without thinking about it is closer than you think.